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Results for "

RNA polymerase inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (66) ADC Cytotoxin (5) ADC Linker (1) Antibiotic (9) Apoptosis (10) Autophagy (1) Bacterial (14) CDK (6) Cytochrome P450 (1) Dengue virus (2) DNA Alkylator/Crosslinker (1) DNA Stain (1) Drug Metabolite (4) Drug-Linker Conjugates for ADC (4) Endogenous Metabolite (5) Filovirus (2) Flavivirus (3) Fungal (3) G-quadruplex (1) HCV (21) HCV Protease (3) HIV (2) HSV (1) Influenza Virus (21) Isotope-Labeled Compounds (6) Keap1-Nrf2 (1) Mitochondrial Metabolism (1) mTOR (1) Nucleoside Antimetabolite/Analog (5) Oxidative Phosphorylation (1) Parasite (5) Phosphatase (2) Reverse Transcriptase (2) RSV (4) SARS-CoV (16) Sirtuin (2) Topoisomerase (2) Virus Protease (1)
By Research Areas:	Cancer (40) Cardiovascular Disease (2) Infection (76) Inflammation/Immunology (3) Metabolic Disease (3)
Click Chemistry:	Azide (4) Alkynes (1)

120

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: DNA/RNA Synthesis Small Interfering RNA (siRNA) PARP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0540

Cynaroside 5+ Cited Publications Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside	Influenza Virus DNA/RNA Synthesis Apoptosis Parasite Bacterial Fungal	Infection Cancer
Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent **RNA polymerase** inhibitor with an IC₅₀ of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-163015

RNA polymerase-IN-1

Others Infection

RNA polymerase-IN-1 (compound 4) is s DNA-dependent RNA polymerase inhibitor. RNA polymerase-IN-1 inhibits CYP isozymes .
HY-163016

RNA polymerase-IN-2

Others Infection

RNA polymerase-IN-2 (compound 5) is s DNA-dependent RNA polymerase inhibitor. RNA polymerase-IN-2 inhibits CYP isozymes .

RNA polymerase-IN-1	Others	Infection
RNA polymerase-IN-1 (compound 4) is s DNA-dependent **RNA polymerase** inhibitor. RNA polymerase-IN-1 inhibits CYP isozymes .

RNA polymerase-IN-2	Others	Infection
RNA polymerase-IN-2 (compound 5) is s DNA-dependent **RNA polymerase** inhibitor. RNA polymerase-IN-2 inhibits CYP isozymes .

HY-16750

Radalbuvir GS-9669	HCV	Infection
Radalbuvir (GS-9669) is a non-nucleoside inhibitor of nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp). Radalbuvir shows strong anti-HCV potency (GT1a intrinsic EC₅₀ = 2.9 nM, GT1b EC₅₀ = 6 nM) .

HY-N0540R

Cynaroside (Standard) Luteolin 7-glucoside (Standard); Luteolin 7-O-β-D-glucoside (Standard)	Apoptosis DNA/RNA Synthesis Parasite Bacterial Influenza Virus Fungal	Cancer
Cynaroside (Standard) is the analytical standard of Cynaroside. This product is intended for research and analytical applications. Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent **RNA polymerase** inhibitor with an IC₅₀ of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-115755

Thio-ITP 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5'-triphosphate; 6-Thio-ITP	DNA/RNA Synthesis	Cancer
Thio-ITP (6-Thioinosine 5′-triphosphate) is an **RNA polymerase** activity competitive inhibitor. Thio-ITP has a high apparent affinity for the polymerases (RNA polymerase I K_i: 40.9 μM; RNA polymerase II K_i: 38.0 μM) .

HY-147916

RNA polymerase II-IN-1	DNA/RNA Synthesis	Cancer
RNA polymerase II-IN-1 (compound 19iv) is a amatoxin, inhibiting RNA polymerase II (Pol II) with an IC₅₀ value of 36.66 nM. RNA polymerase II-IN-1 has higher cytotoxicity against cancer cells and less toxic in normal cells than α-Amanitin .

HY-128917

DNA31

DNA/RNA Synthesis Infection

DNA31 is a potent RNA polymerase inhibitor .

DNA31	DNA/RNA Synthesis	Infection
DNA31 is a potent **RNA polymerase** inhibitor .

HY-147917

RNA polymerase II-IN-2	DNA/RNA Synthesis	Cancer
RNA polymerase II-IN-2 (compound 20iii) is a potent RNA polymerase II (Pol II) inhibitor with K_i value of 9.5 nM. RNA polymerase II-IN-2 has cytotoxicity against cancer cells, and exhibits 2 and 5 fold toxicity than α-amanitin against CHO and HEK293 .

HY-14768

Favipiravir 30+ Cited Publications T-705	DNA/RNA Synthesis Influenza Virus SARS-CoV Bacterial	Infection
Favipiravir (T-705) is a potent viral **RNA polymerase** inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC₅₀ of 341 nM.

HY-115730

RdRP-IN-3

DNA/RNA Synthesis Influenza Virus Infection

RdRP-IN-3 is a promising anti-influenza agent candidate by inhibiting the activity of RNA-dependent RNA polymerase (RdRp).

RdRP-IN-3	DNA/RNA Synthesis Influenza Virus	Infection
RdRP-IN-3 is a promising anti-influenza agent candidate by inhibiting the activity of RNA-dependent RNA polymerase (RdRp).

HY-152294

3′-Deoxy-3′-methyluridine	DNA/RNA Synthesis	Infection
3′-Deoxy-3′-methyluridine is a nucleoside derivative, involving in preparation inhibitors of RNA-dependent RNA viral polymerase .

HY-109047

Adafosbuvir AL-335	HCV DNA/RNA Synthesis	Infection
Adafosbuvir (AL-335), a precursor compound of a uridine-based nucleotide analog polymerase (NS5B) inhibitor, has potent antiviral activity against HCV and acts as a potent inhibitor of HCV RNA polymerase .

HY-126406

Tirandamycin A	Bacterial DNA/RNA Synthesis Parasite Antibiotic	Infection
Tirandamycin A, an antibiotic, is a bacterial RNA polymerase inhibitor. Tirandamycin A has antiamoebic and antibacterial properties .

HY-17025

Rifabutin 4 Publications Verification Ansamycin; LM-427	Bacterial Antibiotic	Infection
Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.

HY-18079

BILB 1941

HCV Infection

BILB 1941 is a potent and specific nonnucleoside inhibitor of the hepatitis C virus (HCV) RNA polymerase in vitro .

BILB 1941	HCV	Infection
BILB 1941 is a potent and specific nonnucleoside inhibitor of the hepatitis C virus (HCV) RNA polymerase in vitro .

HY-13998

Dasabuvir 10+ Cited Publications ABT-333	HCV DNA/RNA Synthesis	Infection
Dasabuvir (ABT-333) is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir inhibits RNA-dependent **RNA polymerase** encoded by the HCV NS5B gene. Dasabuvir inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC₅₀ values of 7.7 and 1.8 nM, respectively .

HY-13998A

Dasabuvir sodium ABT-333 sodium	HCV DNA/RNA Synthesis	Infection
Dasabuvir (ABT-333) sodium is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir sodium inhibits RNA-dependent **RNA polymerase** encoded by the HCV NS5B gene. Dasabuvir sodium inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC₅₀ values of 7.7 and 1.8 nM, respectively .

HY-155110

Antiviral agent 34	Influenza Virus	Infection
Antiviral agent 34 is a potent and orally active antiviral agent against influenza A and B subtypes with an EC₅₀ value of 0.8 nM for H1N1 proliferation. Antiviral agent 34 derivatives inhibited influenza virus proliferation by targeting influenza virus RNA-dependent RNA polymerase. Antiviral agent 34 can be used for influenza virus research .

HY-134909

AS-136A	DNA/RNA Synthesis	Infection
AS-136A is an orally active non-nucleoside inhibitor of the measles virus RNA-dependent RNA polymerase (RdRp) with an IC₅₀ of 2 µM for measles virus .

HY-75800

Lomibuvir 2 Publications Verification VX-222	DNA/RNA Synthesis HCV	Infection
Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the *HCV NS5B polymerase* (RdRp) with a K_d** of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC₅₀ of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis .

HY-10240

Mericitabine 5+ Cited Publications RG 7128; R-7128; PSI 6130 diisobutyrate	HCV	Infection
Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.

HY-152239

RdRP-IN-5	Influenza Virus	Infection
RdRP-IN-5 (compound 20) is a potent influenza virus RNA-dependent RNA polymerase (RdRP) inhibitor. RdRP-IN-5 can be used in research of influenza virus .

HY-149648

JNJ-8003

RSV Infection

JNJ-8003 is a potent inhibitor of RSV Polymerase. JNJ-8003 inhibits nucleotide polymerization of RNA transcription and replication at the early stages .

JNJ-8003	RSV	Infection
JNJ-8003 is a potent inhibitor of RSV Polymerase. JNJ-8003 inhibits nucleotide polymerization of RNA transcription and replication at the early stages .

HY-19610

α-Amanitin 30+ Cited Publications α-Amatoxin	DNA/RNA Synthesis ADC Cytotoxin	Cancer
α-Amanitin is the principal toxin of several deadly poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II.

HY-148478

MMV688845 (R)-GSK1729177A	DNA/RNA Synthesis	Infection
MMV688845 is a nontuberculous mycobacteria (NTM) RNA polymerase inhibitor with bactericidal activity against Mycobacterium abscessus and anti-tuberculosis efficacy .

HY-W015764

T-1105 1 Publications Verification	Flavivirus	Infection
T-1105, a structural analogue of T-705, is a novel broad-spectrum viral *polymerase* inhibitor. T-1105 inhibits the polymerases of RNA viruses after being converted to ribonucleoside triphosphate (RTP) metabolite. T-1105 has antiviral activity against various RNA viruses. T-1105 can be formed by nicotinamide mononucleotide adenylyltransferase .

HY-128916

dmDNA31

Bacterial Infection

dmDNA31 is a rifamycin-class antibiotic that inhibits bacterial DNA-dependent RNA polymerase with potent bactericidal activity against S. aureus .

dmDNA31	Bacterial	Infection
dmDNA31 is a rifamycin-class antibiotic that inhibits bacterial DNA-dependent RNA polymerase with potent bactericidal activity against S. aureus .

HY-152239A

cis-RdRP-IN-5	Influenza Virus	Infection
cis-RdRP-IN-5 (compound 19) is a potent influenza virus RNA-dependent RNA polymerase (RdRP) inhibitor. cis-RdRP-IN-5 can be used in research of influenza virus .

HY-152239B

trans-RdRP-IN-5	Influenza Virus	Infection
trans-RdRP-IN-5 (compound 18) is a potent influenza virus RNA-dependent RNA polymerase (RdRP) inhibitor. trans-RdRP-IN-5 can be used in research of influenza virus .

HY-147903

HIV-1 inhibitor-42	HIV	Infection
HIV-1 inhibitor-42 (compound 5b) is a potent HIV-1 inhibitor, with an IC₅₀ of 0.06 μM. HIV-1 inhibitor-42 inhibits HIV-1 RT RNA-dependent DNA polymerase and DNA-dependent DNA polymerase, with IC₅₀ values of 0.518 and 0.072 μM .

HY-154989

RdRP-IN-6	DNA/RNA Synthesis	Infection Cancer
RdRP-IN-6 (compound 27) inhibits RNA dependent-RNA polymerase (RdRp) with an IC₉₀ value of 14.1 μM. RdRP-IN-6 can be used for research on antiviral and anticancer .

HY-131083

ε-Amanitin	DNA/RNA Synthesis ADC Cytotoxin	Cancer
ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II .

HY-W011834

2'-O-Methylcytidine	HCV	Infection
2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate .

HY-134665

NITD-2	Flavivirus Dengue virus DNA/RNA Synthesis	Infection
NITD-2, a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly .

HY-149050

Viral polymerase-IN-1 hydrochloride	Influenza Virus SARS-CoV	Infection
Viral polymerase-IN-1 hydrochloride, a Gemcitabine (HY-17026) derivative, potently inhibits influenza A and B viruses infection with IC₉₀ values of 11.4-15.9 μM. Viral polymerase-IN-1 hydrochloride is active against SARS-CoV-2 infection. Viral polymerase-IN-1 hydrochloride suppresses influenza virus infection by affecting viral RNA replication/transcription in cells .

HY-N0637

Eriodictyol 3 Publications Verification Huazhongilexone	Keap1-Nrf2 Influenza Virus DNA/RNA Synthesis Endogenous Metabolite	Infection Inflammation/Immunology
Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces Nrf2 signaling pathway. Eriodictyol is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 18 nM.

HY-148167

2'-Deoxy-2'-fluoro-l-uridine	DNA/RNA Synthesis Virus Protease	Infection
2'-Deoxy-2'-fluoro-l-uridine is an L-nucleoside compound. 2'-Deoxy-2'-fluoro-l-uridine is a potent, selective viral **RNA polymerase** inhibitor, thereby inhibiting RNA virus replication .

HY-139442

RdRP-IN-2	SARS-CoV	Infection
RdRP-IN-2 is a RNA dependent RNA polymerase (RdRp) inhibitor. RdRP-IN-2 significantly inhibits SARS-CoV-2 RdRp with an IC₅₀ of 41.2 µM.RdRP-IN-2 also inhibits Feline coronavirus (FIPV) replication .

HY-W004924S

5-Hydroxymethyluracil-d3	Endogenous Metabolite	Others
5-Hydroxymethyluracil-d₃ is the deuterium labeled 5-Hydroxymethyluracil[1]. 5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase[2][3].

HY-W004924

5-Hydroxymethyluracil	Endogenous Metabolite	Others
5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.

HY-17025S

Rifabutin-d7 Ansamycin-d₇; LM-427-d₇	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Rifabutin-d₇ is the deuterium labeled Rifabutin. Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.

HY-12429

Beclabuvir 3 Publications Verification BMS-791325	HCV	Infection
Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC₅₀ of < 28 nM.

HY-125650

Pseudouridimycin 1 Publications Verification PUM	DNA/RNA Synthesis Bacterial Antibiotic	Infection
Pseudouridimycin (PUM), an antibiotic, is a selective bacterial RNA polymerase (RNAP) inhibitor. Pseudouridimycin is a C-nucleoside analogue that is effective against both Gram-negative and Gram-positive bacteria .

HY-N0112

Dihydromyricetin 10+ Cited Publications Ampelopsin; Ampeloptin	mTOR Influenza Virus DNA/RNA Synthesis Autophagy	Infection Cancer
Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 22 μM.

HY-158028

PAN endonuclease-IN-2	Influenza Virus	Infection
PAN endonuclease-IN-2 (compound T-31) is a PA_N endonuclease inhibitor (IC₅₀: 0.15 μM) and antiviral agent with broad-spectrum anti- Influenza activity. PAN is the N-terminal PA subunit of the polymerase-RNA complex and the dependent endonuclease (CEN) active site. PAN initiates RNA replication by promoting cleavage of the RNA strand and allowing the polymerase to begin synthesizing new RNA molecules. PAN endonuclease-IN-2 targets both the influenza HA and RdRp complexes, thereby interfering with viral entry into host cells and viral replication .

HY-155868A

5-Azacytidine 5′-triphosphate sodium 5-aza-CTP sodium	Others	Others
5-Azacytidine 5’-triphosphate sodium is a cytidine analog. 5-Azacytidine 5’-triphosphate sodium inhibits the incorporation of [ ³H]CTP, but not [ ³H]UTP, into RNA in the DNA-dependent RNA polymerase reaction .

HY-12484

BMH-21 5 Publications Verification	DNA/RNA Synthesis	Cancer
BMH-21 is a first-in-class DNA intercalator which inhibits RNA polymerase I (Pol I) transcription. BMH-21 possesses anticancer activity .

HY-145840

Pol I-IN-1

DNA/RNA Synthesis Cancer

Pol I-IN-1 is a potent RNA polymerase I (Pol I) inhibitor with IC₅₀ 0.21 µM for the Pol I large catalytic subunit RPA194 .

HY-148231

Dideoxy-amanitin	DNA/RNA Synthesis ADC Cytotoxin	Cancer
Dideoxy-amanitin (compound 2), an α-Amanitin (HY-19610) derivative, is a potent and selective RNA polymerase II allosteric inhibitor with an IC₅₀ value of 74.2 nM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0540

Cynaroside 5+ Cited Publications Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside	Infection Structural Classification Flavonoids Classification of Application Fields Flavones Centaurea ornata Phenols Polyphenols Umbelliferae Plants Disease Research Fields	Influenza Virus DNA/RNA Synthesis Apoptosis Parasite Bacterial Fungal
Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent **RNA polymerase** inhibitor with an IC₅₀ of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-N0637

Eriodictyol 3 Publications Verification Huazhongilexone	Classification of Application Fields Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids other families Microorganisms Flavonones Phenols Polyphenols Inflammation/Immunology Disease Research Fields	Keap1-Nrf2 Influenza Virus DNA/RNA Synthesis Endogenous Metabolite
Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces Nrf2 signaling pathway. Eriodictyol is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 18 nM.

HY-N0540R

Cynaroside (Standard) Luteolin 7-glucoside (Standard); Luteolin 7-O-β-D-glucoside (Standard)	Structural Classification Flavonoids Phenols	Apoptosis DNA/RNA Synthesis Parasite Bacterial Influenza Virus Fungal
Cynaroside (Standard) is the analytical standard of Cynaroside. This product is intended for research and analytical applications. Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent **RNA polymerase** inhibitor with an IC₅₀ of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-126406

Tirandamycin A	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Anti-parasitic Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial DNA/RNA Synthesis Parasite Antibiotic
Tirandamycin A, an antibiotic, is a bacterial RNA polymerase inhibitor. Tirandamycin A has antiamoebic and antibacterial properties .

HY-131083

ε-Amanitin	Natural Products Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	DNA/RNA Synthesis ADC Cytotoxin
ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II .

HY-W004924

5-Hydroxymethyluracil	Natural Products Classification of Application Fields Other disease Source classification Other Diseases Disease markers Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.

HY-125650

Pseudouridimycin 1 Publications Verification PUM	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	DNA/RNA Synthesis Bacterial Antibiotic
Pseudouridimycin (PUM), an antibiotic, is a selective bacterial RNA polymerase (RNAP) inhibitor. Pseudouridimycin is a C-nucleoside analogue that is effective against both Gram-negative and Gram-positive bacteria .

HY-N0112

Dihydromyricetin Maximum Cited Publications 12 Publications Verification Ampelopsin; Ampeloptin	Infection Flavanonols Structural Classification Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	mTOR Influenza Virus DNA/RNA Synthesis Autophagy
Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 22 μM.

HY-135780

3'-Deoxyuridine-5'-triphosphate 3'-dUTP	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Endogenous Metabolite
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into *RNA* with a K_i value of 2.0 μM .

HY-135780A

3'-Deoxyuridine-5'-triphosphate trisodium 3'-dUTP trisodium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Endogenous Metabolite
3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate trisodium strongly and competitively inhibits the incorporations of UTP into *RNA* with a K_i value of 2.0 μM .

HY-100126

Tubercidin 4 Publications Verification 7-Deazaadenosine	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antiviral Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial DNA/RNA Synthesis Influenza Virus Antibiotic
Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC₅₀ of 0.02 μM . Tubercidin inhibits polymerases by incorporating DNA or *RNA, thereby inhibiting* DNA replication, RNA and protein synthesis . Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP . Tubercidin has antiviral activity .

HY-17580

Fidaxomicin 5 Publications Verification OPT-80; PAR-101	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Phenols Polyphenols Antibacterial Disease Research Disease Research Fields	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic
Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent **RNA polymerase** inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC₉₀=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research .

HY-131081

γ-Amanitin	Structural Classification Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Source classification Disease Research Fields Cancer	DNA/RNA Synthesis ADC Cytotoxin
γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC₅₀ of 163.1 ng/mL .

HY-B0914A

10-Undecenoic acid zinc salt Zinc undecylenate	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Fungal DNA/RNA Synthesis
10-Undecenoic acid zinc salt is a RNA-dependent RNA polymerase (RdRp) inhibitor, with an IC₅₀ of 1.13, 21.33 and 1.79 μM for WT-RdRp, D535ARdRp and D692A-RdRp, respectively. 10-Undecenoic acid zinc salt reduces infectious virus yield in Huh7 cells with an EC₅₀ of 7.43 μM. 10-Undecenoic acid zinc salt has anti-infective and anti-fungal activity. 10-Undecenoic acid zinc salt can be used for the research of Zika virus (ZIKV) .

Cat. No.	Product Name	Chemical Structure

HY-17025S

Rifabutin-d7
Rifabutin-d₇ is the deuterium labeled Rifabutin. Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.

HY-W004924S

5-Hydroxymethyluracil-d3
5-Hydroxymethyluracil-d₃ is the deuterium labeled 5-Hydroxymethyluracil[1]. 5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase[2][3].

HY-W011834S

2'-O-Methylcytidine-d3
2'-O-Methylcytidine-d₃ is deuterium labeled 2'-O-Methylcytidine (HY-W011834). 2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.

HY-109025AS

Baloxavir-d5
Baloxavir-d₅ is deuterium labeled Baloxavir. Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity[1][2].

HY-10241S

Simeprevir-13C,d3

Simeprevir- ¹³C,d₃ is the ¹³C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses[1][2][5].

HY-17580S

Fidaxomicin-d7
Fidaxomicin-d₇ (OPT-80-D7) is the deuterium labeled Fidaxomicin. Fidaxomicin (OPT-80), a macrocyclic RNA polymerase inhibitor, has a narrow spectrum of activity. Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora[1][2].

HY-W751835

Baloxavir-d4

15+ Cited Publications

Baloxavir-d₄ (Baloxavir acid-d₄; S-033447-d₄) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d₄ (Baloxavir-d₄ acid), derived from the proagent Baloxavir-d₄ marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d₄ inhibits viral RNA transcription and replication and has potently antiviral activity .

Cat. No.	Product Name		Classification

HY-16200

Ethynylcytidine ECyD; TAS-106; 3'-C-Ethynylcytidine		Alkynes
Ethynylcytidine (ECyD), a nucleoside analog and a potent inhibitor of RNA synthesis, inhibits RNA polymerases I, II and II. Ethynylcytidine has robust antitumor activity in a wide range of models of cancer . Ethynylcytidine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10444

R-1479 3 Publications Verification 4'-Azidocytidine		Azide
R-1479 (4'-Azidocytidine), a nucleoside analogue, is a specific inhibitor of RNA-dependent RNA polymerase (RdRp) of HCV. R-1479 inhibits HCV replication in the HCV subgenomic replicon system (IC₅₀=1.28 μM) . R-1479 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-10443

Balapiravir 3 Publications Verification Ro 4588161; R1626		Azide
Balapiravir (Ro 4588161; R1626) is an orally active proagent of a nucleoside analogue inhibitor of the RNA-dependent RNA polymerase (RdRp) of HCV (R1479; 4'-Azidocytidine). Balapiravir has anti-HCV activity . Balapiravir is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-10443A

Balapiravir hydrochloride Ro 4588161 hydrochloride; R1626 hydrochloride		Azide
Balapiravir hydrochloride (Ro 4588161 hydrochloride; R1626 hydrochloride) is an orally active proagent of a nucleoside analogue inhibitor of the RNA-dependent RNA polymerase (RdRp) of HCV (R1479; 4'-Azidocytidine). Balapiravir hydrochloride has anti-HCV activity . Balapiravir (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-151829

Fmoc-L-Asn(EDA-N3)-OH		Azide
Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II .

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